Contract Development Services

BINEX provides customized contract development services.

Leveraging diverse experiences in biopharmaceutical development and production, BINEX provides cell line development, process development, and analytical method development services, taking into account the specific characteristics of the products.
Utilizing developed processes and analytical methods, we can provide research-grade production up to 50 L scale under Non-GMP conditions. Additionally, we offer services for protein structure and characterization analysis required during biologics development stages.

Cell Line Development

BINEX provides cell line development service that ensure the establishment of cell lines with assured productivity, viability, monoclonality, and sterility. Through our cell line development services, it is possible to establish cell lines utilizing various expression systems (DHFR, GS, etc.) and we also performs selective cell line screening through pre-assessment of yield and quality.

• Early-stage optimal cell line selection is possible through comparison of material characteristics and productivity across different expression systems
• Minimization of development risks through the introduction of validated cell lines
• Single clone selection: Equipped with state-of-the-art equipment for the selection of high-producing cell lines
• Manufacturing of Research Cell Bank (RCB) and conducting cell line stability testing.
• Confirmation of early-stage cell line production and developability evaluation of expressed antibody

Process FlowCell Line Development

• 
  Expression vector
  construction
• 
  Transfection &
  stable pool selection
• 
  Single cell cloning
  ClonePix & LDC
  •  Monoclonality
• 
  Performance test
  via Fed-batch culture
• 
  RCB Generation
  •  Mycoplasma test
  •  Virus testing(MMV)
• 
  Stablilty test